The concept of the Ascension (Mi'raj) in Islamic philosophy, while preserving its spiritual dimensions, can be regarded as a turning point for dialogue between religion and the natural sciences, opening new perspectives for understanding the relationship between humanity, the cosmos, and God. This fundamental study, employing philosophical analysis, examines the Prophet Muhammad’s Ascension and the approximate location of his encounter with Gabriel in the vicinity of the star Nitaq, or Alnitak, the easternmost star of the Belt of Orion. In Islamic hadiths, Nitaq is known as a covering over thousands of worlds and has a longstanding association with concepts such as the legendary cities of Jabulqa and Jabarqa, the peoples of Ad and Thamud, and their ancestors, known as Ad al-Ula. This star is aligned with monumental structures across the world, and ancient great civilizations regard the vicinity of this star as the origin of humanity. By correlating these concepts, the phenomena of Qaba Qawsayn, Sidrat al-Muntaha, and the Highest Horizon (Ufuq al-Ala), mentioned in Surat al-Najm in connection with the Prophet Muhammad’s Ascension, may be reread within a cosmic framework through theories such as black holes, wormholes, cosmic strings, Einstein rings, and gravitational lensing, in light of contemporary scientific concepts. This study introduces the Prophet Muhammad’s Ascension as a proposed model for bringing together Islamic mysticism and contemporary cosmology.